Biophysics Theoretical Biophysics PTB004


Chromosomal replication is a dynamic process that is initiated by DNA unwinding. To understand the DNA unwinding mechanism at replication initiation, we studied the formation of the structure of a DNA-protein complex at the replication origin. This is called the replication initiation complex. In the video, we modeled a part of the initiation complex by coarse-grained molecular dynamics simulation. In the video, DNA is shown in gray and DNA-bending protein (Integration Host Factor) is shown in black. The molecules that form a pentamer on the DNA are DnaA proteins. For visibility, we colored DnaA proteins in two alternating ways: blue (oligomerization domain) and light purple (DNA-binding domain); or green (oligomerization domain) and yellowish green (DNA-binding domain).



Prefecture Kyoto Use of Microscope Don't Use
Region Yoshida Campus, Kyoto University Use of Automatic Shooting Devices Don't Use
Shooting Date 2017/2/4 Use of Fluorescent Probe Don't Use
Shooting Time --- Use of Infrared Don't Use
Photographer Masahiro SHIMIZU Shooting Interval (Sec.) 使用しない
Copyright Holder Masahiro SHIMIZU Shooting Speed ---

in Japanese